Journal article
A Transcription Factor Map as Revealed by a Genome- Wide Gene Expression Analysis of Whole-Blood mRNA Transcriptome in Multiple Sclerosis
C Riveros, D Mellor, KS Gandhi, FC Mckay, MB Cox, R Berretta, SY Vaezpour, M Inostroza-Ponta, SA Broadley, RN Heard, S Vucic, GJ Stewart, DW Williams, RJ Scott, J Lechner-Scott, DR Booth, P Moscato
Plos One | Published : 2010
Abstract
Background: Several lines of evidence suggest that transcription factors are involved in the pathogenesis of Multiple Sclerosis (MS) but complete mapping of the whole network has been elusive. One of the reasons is that there are several clinical subtypes of MS and transcription factors that may be involved in one subtype may not be in others. We investigate the possibility that this network could be mapped using microarray technologies and contemporary bioinformatics methods on a dataset derived from whole blood in 99 untreated MS patients (36 Relapse Remitting MS, 43 Primary Progressive MS, and 20 Secondary Progressive MS) and 45 age-matched healthy controls. Methodology/Principal Findings..
View full abstractGrants
Awarded by Australian Research Council
Funding Acknowledgements
[ "This project had the following sources of funding: Australian Research Council Centre of Excellence in Bioinformatics (PM), Australian Research Council Linkage Project LP0776744 (ANZgene, MS Research Australia), Australian Research Council Discovery project DP0559755 (PM and RB) and DP0773279 (PM, RS and DM). The University of Newcastle via central funding to the Priority Research Centre in Bioinformatics, Biomarker Discovery and Information-based Medicine (PM, RS, RB, CR, DM, MIP). The University of Newcastle's Strategic Initiative Fund for project: Newcastle Bioinformatics Initiative, 2003-2007 (PM, RB, MIP). Universidad de Santiago de Chile, Departamento de Investigaciones Cientificas y Tecnologicas project 060919IP (MIP). Australia Research Council Biogen Idec PhD award (KG). Grant from the John Hunter Hospital Charitable Trust Fund and a special grant from Macquarie Bank (MBC). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.", "We would like to thank people with MS in Australia and New Zealand for supporting this research. We are grateful to Multiple Sclerosis Research Australia for supporting this project, and in particular to the expediting efforts from Mr Jeremy Wright and Ms Christine Remediakis." ]